Genomics meets Wireless: Elegant, individualized medicine

By: Brian Dolan | Jul 28, 2009        

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Dr. Eric TopolThe way that we listen to music these days is completely different from the way it used to be; the way we communicate via electronic messaging is also very different; so is the way we read books thanks to devices like Amazon’s Kindle, explained The West Wireless Health Institute’s Dr. Eric Topol at the Qualcomm Smart Services Summit in San Diego this morning.

“Wouldn’t it be natural — knowing that in a very short period of time our world has changed — that we could apply these devices to healthcare,” Topol continued. “Reading, listening to music and communicating… healthcare can change in the same way.”

Topol noted that thanks to “extremely ingenius developments in wireless sensors” coupled with breakthroughs in genomics, we are now able to “profile the individual in an exquisite and elegant way.”

Topol gave three key examples for ways that genomic profiling can be paired with wireless sensor technologies to bring about these elegant preventive medicine services.

Obesity: Topol noted that the percentage of obese people in the U.S. has doubled since 1991 and that it continues to rise, calling it seemingly “unstoppable.” In California, for example, about 10 percent of the population was considered obese in 1991, but now it’s around 21 percent of the population.

We now have uncovered the the genetic contribution to non-syndromic human obesity, Topol explained: “We now know at birth who is likely to be unequivocablly associated with the propensity to become obese.”

A wireless health solution like the one Philometron is developing, would enable users to keep track of “calories in and calories out” through the use of a wireless “band aid” equipped with sensors that can report the metrics to the user’s smartphone.

“That’s doable — it’s just a matter of when,” Topol said. “… [People] sure aren’t going to be looking up [their calorie intake] on a calorie book… This is the biggest chance we have at improving obesity around the world.”

Atrial fibrillation: Another example where genomics can work together with wireless health services is with atrial fibrillation. Topol said we are now able to screen the genome for the likelihood of atrial fibrillation. After finding a person is genetically predisposed to atrial fibrillation, we would then know to do a wireless 30 day cardiac rhythm monitoring, Topol said.

“That can only be captured via wireless means,” Topol said. Once the arrythmias are pinpointed there are ways to potentially cure it whether through ablation or inhibitory drugs, Topol explained.

Breast Cancer: Topol said we also already know the genes that predispose people to breast cancer. We can partition women who are more likely to get breast cancer and screen this group much more in-depth — beyond mammographies — using ultrasound to monitor their condition much more closely. Some of these ultrasound can even be conducted at home using a wireless ultrasound device that can then transmit the images to clinicians.

  • http://3gdoctor.wordpress.com David Doherty

    I find it disappointing that the highly respected Dr Topol has picked such privacy evoking solutions to make his point. Whilst I have no doubt that his patients would have no problem trusting his personal advocacy for such novel solutions, in the wider patient markets these solutions will probably reach patients via commercial sales and marketing tactics.

    Scientific breakthroughs and the sharing of personal genomic data aren’t required in order for a consumer to download a MP3, send a SMS message or to read the Wall Street Journal on their Amazon Kindle.

    IMHO I think he would have made a much more persuasive argument for the use of wireless sensory technologies if he had used examples that don’t require users having to share such highly personal information. For example instead of using genomic data obesity could be determined by a combination of an individuals BMI (eg bluetooth weighing scales), activity levels (eg Nokia Sports Tracker) and the answers to a brief questionnaire to rule out any syndromes/PMH (eg. medicalhistory.com).

  • http://mobihealthnews.com Brian Dolan

    Hi David,

    Maybe I didn’t explain it well enough in my post — Topol suggests we “screen” people for the genes that have been shown to indicate the person is predisposed to becoming obese. Then we can use tools like caloric intake sensors to help them manage their weight to avoid obesity — the tools you mention are certainly in that same wheelhouse.

    Further — Topol’s vision did not include any “sharing” of genomic data with anyone other than the person doing the genetic screening — assumedly their doctor. While that is perhaps not a comfortable idea for many, just trying to be clear — no “sharing” of genomic data was discussed beyond that.

    Brian

  • http://Aurametrix.com Irene Gabashvili

    I agree with David, no need to screen people for “obesity” genes, predisposition can be inferred from less expensive and much simpler observations.

    Besides, instead of “thrifty genotype”, scientists are now talking about but “thrifty epigenotype”, it is not necessarily inherited, it could be affected by mother’s nutrition before and during pregnancy and lactation. So it’s more than just genes.

    Aurametrix is working on a “calories in/out” solution too, although the primary focus is on food components affecting quality of life (IBS, TMAU, etc), not just calories.

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