In its most recent S Health app update, Samsung added support for all Samsung smartphones, starting with the Galaxy S3. Samsung also extended support for some non-Samsung Android phones that have Android OS 4.4 or above. The company posted in its app update that tablets and some mobile devices may not be supported, though the company does not specify which.

S Health, which was first announced in 2012, helps users to track their health using integrated data from third party apps and devices.

The app helps users track activity, fitness, and nutrition and also offers digital coaching programs to help users reach their health goals. S Health uses this data to create health information summaries for users. People can also personalize their S Health dashboard by adding or removing goals and picking which health metrics they want to track. According to the app store description, S Health has between been downloaded 50 million and 100 million times.

At the beginning of 2014,  Samsung announced that it received FDA 510(k) clearance for one version of S Health. Later that year, at an event, Samsung Chief Medical Officer and VP for Global Healthcare David Rhew explained that the reason for the company's FDA clearance was to make S Health work on the enterprise side, with hospitals and physicians and that S Health, which began as a consumer fitness application, was increasingly moving into the chronic disease and medical side.

In January, rumors surfaced that Samsung’s upcoming Galaxy S6 will feature a number of interchangeable phone covers that will provide different functionality to users, including a case with built-in health sensors. One would improve the phone’s camera, one would add an e-ink screen, and one, apparently, would add some kind of glucose meter that would upload data directly into S Health.